The Egyptian Journal of Bronchology
JUNE 2010 |
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ORIGINAL ARTICLE
ROLE OF ADENOSINE DEAMINASE (ADA) IN THE DIAGNOSIS OF PULMONARY TUBERCULOSIS
By
Khalid Hassanein,1 Hossam Hosny,1 Randa Mohamed,2 Wagdy Abd El- Moneim3
1Chest Department, Faculty of medicine, Cairo University, 2Chemical pathology department, Faculty of medicine, Cairo University, 3General Directorate for chest diseases, Ministry of health, Egypt
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Background:
Tuberculosis is still one of the major health problems in the world with more than 9 million new cases and 3 million deaths each year. Rapid and accurate diagnosis of symptomatic patients is a cornerstone of global tuberculosis normal strategies. Deficiencies in current case-finding tools in disease endemic countries have made it difficult to ensure access to good diagnostics at all health service levels, leaving many patients undiagnosed.
Objective:
A case control study aimed to assess the role of adenosine deaminase level in serum and Broncho Alveolar Lavage (BAL) in the diagnosis of pulmonary tuberculosis.
Methods:
Samples of serum and bronchoalveolar Lavage (BAL) were taken from 50 Egyptian patients to assess the level of Adenosine deaminase (ADA) in serum & broncho alveolar lavage fluid (BALF).
Results:
The results of this study showed that patients with pulmonary tuberculosis had significantly higher ADA level in serum and BALF than patients with non- tuberculosis lung diseases (P< 0.001) with cut off point obtained, in serum ADA level was 26.2 u/l, with sensitivity and specificity were 95% and 83.3% respectively and positive predictive value was 79.2%. In BALF ADA level, the cut off point was 2.5 u/l, with sensitivity and specificity were 100% and 83.3% respectively and positive predictive value was 80%.
Conclusion:
Adenosine deaminase (ADA) in pulmonary tuberculosis patients revealed significantly increased level in both serum and BALF for all patients with pulmonary tuberculosis compared to ADA level of cancer, pneumonia and normal persons.
Keywords:
Tuberculosis, ADA, Serum, BAL.
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